White Powder Warfarin sodium CAS 129-06-6 C19H15O4.Na
- mojin
- China
- 7 days
- 500 ton/month
1. The following conditions should be used with caution: cachexia, asthenia, fever, chronic alcoholism, active tuberculosis, congestive heart failure, severe hypertension, subacute bacterial endocarditis, menorrhagia, threatened abortion, etc.
2. During the long-term application of the minimum maintenance dose, if surgery is required, vitamin K1 injection 50mg can be injected, but the drug should be stopped before central nervous system and eye surgery. Stool occult blood should be examined after gastrointestinal surgery.
3. Excessive amounts may cause various kinds of bleeding, so PT+A should be monitored during medication. Note whether other drugs taken at the same time have any effect on this product, so as to adjust the dose in time.
4. A small amount of this product can be secreted into the milk, but the concentration of the drug in the milk and infant plasma is very low, which has little effect on the infant, but the bleeding situation of the suckle should still be observed.
Warfarin sodium, also known as phenylacetone coumarin, plays a competitive role in inhibiting vitamin K. Vitamin K epoxide changes into hydroquinone structure in the body, participates in the synthesis of prothrombin (coagulation factor Ⅱ), participates in the gamma-carboxylation of glutamic acid residues at the end of coagulation factor Ⅶ, Ⅸ and Ⅹ protein, resulting in the inactivation of the precursor of coagulation factor Ⅱ, Ⅸ and Ⅹ, thus inhibiting the occurrence of blood coagulation process. The effect of warfarin sodium depends on the depletion of the above 4 coagulation factors in the body, so it can be used with heparin at the early stage of medication.
Basic information
Chemical formula: C19H15NaO4
Molecular weight: 330.310
CAS number: 129-06-6
EINECS No. : 204-929-4
Physical and chemical properties
Density: 1.307g/cm3
Boiling point: 515.2ºC
Flash point: 188.8ºC
Appearance: White or light yellow powder
Keep out of light and sealed
This product is white crystalline powder, odorless.
This product is highly soluble in water, easily soluble in ethanol, and almost insoluble in trichloromethane or ether.
