White Powder Levamisole CAS 14769-73-4

Brand Mojin
Product origin China
Delivery time In stock
Supply capacity 50000/month

Product Name:Levamisole
Synonyms:L-6-PHENYL-2,3,5,6-TETRAHYDROIMIDAZOL(2,1-B) THIAZOLE;IMMUNOPURE(R) PHOSPHATASE SUPPRESSOR;LEVAMISOLE;LEVAMISOLE BASE;(s)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole;lepuron;levomysol;l-tetramisole

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CAS:	14769-73-4
MF:	C11H12N2S
MW:	204.29
EINECS:	238-836-5
Product Categories:
Mol File:	14769-73-4.mol

Levamisole Chemical Properties

Melting point	60-61.5°
alpha	D25 -85.1° (c = 10 in chloroform)
Boiling point	344.4±45.0 °C(Predicted)
density	1.32±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
pka	10.00±0.40(Predicted)
CAS DataBase Reference	14769-73-4(CAS DataBase Reference)
EPA Substance Registry System	Levamisole (14769-73-4)

Levamisole Usage And Synthesis

Pharmacology and mechanism of action	Levamisole is the L-isomer of tetramisole and is more active than the racemic mixture. It was introduced in 1966 as a veterinary drug and a little later as a human anthelminthic drug against ascariasis. The drug has also shown to be effective against hookworms (Ancylostoma duodenale and Necator americanus), but results of reported studies are inconsistent ^[1]. The mechanism of action of levamisole in helminthiasis is through its stimulation of autonomic ganglia (nicotinic receptors) of the worms. On exposure to the drug, immature and adult worms show spastic contraction followed by tonic paralysis. This mechanism seems to be common to other anthelminthics such as pyrantel and bephenium hydroxynaphthoate ^[2]. In higher doses, levamisole acts as an immunostimulant. It restores depressed cell-mediated immune mechanisms in peripheral T-lymphocytes, but may have marginal effects in immunologically competent individuals ^[3]. The clinical implication of this effect in the treatment of helminthiasis is unknown.
Indications	Monoinfections with Ascaris lumbricoides. In polyinfections, mebendazole is the drug of choice.
Side effects	During the treatment of nematode infections the drug produces minor side effects including nausea, vomiting, abdominal pain and headache^{[4, 5]}. During prolonged treatment as an immunomodulator in rheumatic arthritis and in cancer patients, serious side effects such as blood disorders (agranulocytosis, neutropenia and thrombocytopenia), kidney damage, influenza-like reactions, vasculitis, photosensitivity and allergy to the drug have been reported ^{[6, 7]}.