Teniposide
Teniposide CAS 29767-20-2
Teniposide CAS 29767-20-2
Teniposide CAS 29767-20-2
Tenipside, a semi-synthetic derivative of podophyllotoxin, is a cycl-specific cytotoxic drug that acts on cells late in the S or early G2 cycle by preventing them from entering mitosis. This product also causes DNA single strand breakage, the number of breakage is 5 times that of Vp-16, the mechanism of action is to inhibit type I topoisomerase. The main metabolites are hydroxyl acid, picralactone derivatives and its glycoside group, among which the glycoside group is active to DNA. 39.5% is excreted in urine and 43.1% in stool.
Usage
Tenipside is mainly used for leukemia, malignant lymphoma, neuroblastoma, brain tumor, Hodgkin's disease, bladder cancer, small cell lung cancer and so on.
For leukemia, malignant lymphoma, neuroblastoma, bladder cancer and small cell lung cancer.
Teniposideisasemisyntheticderivativeofpodophyllotoxinwithantineoplasticactivity.TeniposideformsaternarycomplexwiththeenzymetopoisomeraseIIandDNA,resultingindose-depChemicalbookendentsingle-anddouble-strandedbreaksinDNA,DNA:proteincross-links,inhibitionofDNAstrandreligation,andcytotoxicity.ThisagentactsinthelateSorearlyGphaseofthecellcycle.
Product Description
CAS | 29767-20-2 |
| English Name | Teniposide |
| MF | C32H32O13S |
| MW | 656.65 |
| EINECS | 249-831-2 |
| Meting Point | 244-247°C |
| Boling Point | D20 -107° (9:1 chloroform/methanol) |
| λmax | 283nm(MeOH)(lit.) |
Packaging Details
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