High Purity Raw Material Nintedanib Pharmaceutical Powder CAS No. 656247-17-5 Nintedanib
High Purity Raw Material Nintedanib Pharmaceutical Powder CAS No. 656247-17-5 Nintedanib
High Purity Raw Material Nintedanib Pharmaceutical Powder CAS No. 656247-17-5 Nintedanib
High Purity Raw Material Nintedanib Pharmaceutical Powder CAS No. 656247-17-5 Nintedanib
High Purity Raw Material Nintedanib Pharmaceutical Powder CAS No. 656247-17-5 Nintedanib
Packaging Details
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Basic information:
Specification of Analysis
| ITEMS | SPECIFICATION | TESTRESULTS |
| Appearance | Off-white or white powder | Conforms |
| Identification | HPLC,NMR;LC-MS | Conforms |
| Related substances | Individual impurity≤0.5% | 0.09% |
| Total impurities≤1.0% | 0.20% | |
| Loss on drying | ≤0.5% | 0.3% |
| Residue on ignition | ≤0.1% | 0.04% |
| Heavy metals | ≤10ppm | Conforms |
| Assay | ≥98.0 % | 99.1% |
Nintedanib
is an anti-angiogenesis anti-cancer agent. Nintedanib is an
indolinone-derived drug that inhibits the process of blood vessel
formation (angiogenesis)Nintedanib,
marketed under the brand names Ofev and Vargatef, is an oral medication
used for the treatment of idiopathic pulmonary fibrosis (IPF) and along
with other medications for some types of non-small-cell lung cancer.
Common side effects include abdominal pain, vomiting, and diarrhea. It
is a small molecule tyrosine-kinase inhibitor, targeting vascular
endothelial receptor (VEGFR), fibroblast receptor (FGFR) and platelet
derived receptor (R). It was developed by Boehringer Ingelheim. At an
assumed cost of 39,300 pounds per year it does not appear to be cost
effective for IPF in the United Kingdom.
Application
Nintanib
targets platelet-derived receptors (α and β), fibroblast receptors
(FGFR1-3), vascular endothelial receptors (VEGFR1-3), and the adenosine
triphosphate ( ATP) binding sites competitively bind, block the signal
pathway of fibrosis process, inhibit the proliferation, metastasis and
transformation of fibroblasts, thereby slowing the progression of IPF
disease.
Packing
Liquid:
Iron drum & plastic drum packaging
25kg /drum
170kg per unit
IBC/ISO tank
Solid
Plastic bag & kraft paper bag & fiber drum
1kg per bag
25kg per bag/drum
1-10 kgs packaging aluminum foil bag inside and carton box outside.
25kgs packaging fiber drum outside and plastic bag inside.
Shipping
Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.
For mass orders, it will be delivered by air or sea.
Depending on your location, please allow 1-5 business days for your order to arrive.
For small order, please expect 3-7 days by UPS DHL EMS.
For mass order, please allow 5-8 days by Air, 15-30 days by Sea.
