Properties of 2-Aminoacetophenone
Properties of 2-Aminoacetophenone
Properties of 2-Aminoacetophenone
Properties of 2-Aminoacetophenone
Introduction
O-aminophenone is an important fine chemical intermediate, such as the preparation of a high acidity ionic liquid catalytic synthesis of 2-aryl-2, 3-dihydro-4 (1H) -quinolone derivatives, belongs to the field of chemical material preparation technology. The invention relates to a method for catalytic synthesis of 2-aryl-2, 3-dihydro-4 (1H) -quinolone derivatives of a high acidity ionic liquid. The method uses o-aminophenone and aromatic aldehyde as reaction raw materials, in which o-aminophenone is an important fine chemical intermediate, such as preparing a high acidity ionic liquid for catalytic synthesis of 2-aryl-2. The method of 3-dihydro-4 (1H) -quinolone derivatives belongs to the technical field of chemical materials preparation. The invention relates to a method for catalytic synthesis of 2-aryl-2, 3-dihydro-4 (1H) -quinolone derivatives by high acidity ionic liquid. The method takes o-aminophenone and aromatic aldehydes as reaction raw materials and syntheses 2-aryl-2, 3-dihydro-4 (1H) -quinolone derivatives under the catalytic action of high acidity ionic liquid catalyst. By selecting specific ionic liquid with high acidity as catalyst and optimizing the process parameters of the reaction, the shortcomings of large amount of catalyst, relatively poor recycling performance, complex product purification process and product yield need to be further improved in the existing synthesis process can be effectively overcome. The synthesis of 2-aryl-2, 3-dihydro-4 (1H) -quinolone derivatives under the catalytic action of acidity ionic liquid catalyst. By selecting specific high acidity ionic liquid as catalyst, the reaction process parameters were optimized. Therefore, it can effectively overcome the shortcomings of large amount of catalyst, relatively poor recycling performance, complex product purification process and product yield to be further improved in the existing synthesis process.
Usage
The invention relates to a preparation method of o-aminophenone, which includes: in anhydrous or nearly anhydrous solvent, methyl lithium and indophenic anhydride react at a reaction temperature below -50℃, the reaction is completed, and the target product is obtained after treatment.
300mL(1mol/L tetrahydrofuran) methyl lithium was added into the dry reaction bottle. After nitrogen replacement, it was cooled to -75℃ under the protection of nitrogen, and tetrahydrofuran (25mL) mixture of indiored anhydride (16.3g, 0.1mol) was slowly added. After drip, it was kept at -75℃ for reaction. Whole process nitrogen protection, process TLC tracking. After the reaction, pour into 80ml water, stir for 30min, stratification, upper layer drying concentrated 13.6g, decompression distillation to obtain the target product 11.7g, the content of 99.1%, molar yield 87.5%.
Product Description
CAS | 551-93-9 |
| English Name | 2-Aminoacetophenone |
| MF | 551-93-9 |
| MW | 135.16 |
| EINECS | 209-002-8 |
| Meting Point | 20 °C |
| Boling Point | 85-90 °C0.5 mm Hg(lit.) |
| FEMA | 3906 | 2-AMINOACETOPHENONE |
| Merck | 14,413 |
| JECFA Number | Moderate toxicity |
Packaging Details
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